Klaus Gorlinger: TEM-guided POC Coagulopathy Management

Dr. Klaus Gorlinger is one of the leading international experts in the management of coagulopathy and has dedicated his career to perfecting the art & science of hemostatic resuscitation.  One of his major fields of expertise is the use of Point of Care (POC) guided algorithms for goal directed coagulopathy management.  Dr. Gorlinger is now the medical director of TEM international based out of Munich, Germany.  We were honored to have Dr. Gorlinger visit the city of Baltimore after the Consensus Conference on Thromboelastometry Based Transfusion Guidelines for Early Trauma Resuscitation in Philadelphia this past September.

This lecture is just a sneak preview at how the thought leaders in coagulopathy management are changing the landscape of resuscitation.


Conventional vs. Point-of-care (POC)

  • Conventional coagulation tests are static, and can have up to a 60 minute turn around time
  • Bedside ROTEM (thromboelastometry) can give dynamic/functional coagulopathy diagnostics in as quick as 10 minutes

TEM parameters

  • ROTEM has a number of different coagulation tests to isolate individual targets of coagulopathy management
    • Extrinsic pathway (EXTEM)
    • Intrinsic pathway (INTEM)
    • Fibrin clotting function (FIBTEM)
    • Heparin effect (HEPTEM)
    • Fibrinolysis (APTEM)
    • *Direct thrombin inhibitor (DTI) effect (ECATEM)

Abnormal TEM Tracings, Interventions

ROTEM Assays       Abnormal TEM Interventions

TEM-Driven Coagulopathy Management Algorithm

EBM A10 Trauma Algorithm

Pearl:  Platelet count/function and fibrinogen level will significantly impact clinical bleeding, the critical A10 is 45 mm, but you can get there many different ways!

Platelets and Fibrinogen

 Ok, so Dr. Gorlinger takes a nice shot at massive transfusion, brute force coagulopathy management, and America (kidding!)… but is this the future of mainstream coagulopathy management?  I’d love to hear what you all think, please leave your comments below!

 

Suggested Readings

  1. Callum, J. Ten things you need to know about ROTEM.  Sunnybrook Health Sciences Centre, University of Toronto.  2013. [ROTEM.pdf]
  2. Tanaka KA, Bolliger D, Vadlamudi R, Nimmo A. Rotational thromboelastometry (ROTEM)-based coagulation management in cardiac surgery and major trauma. J Cardiothorac Vasc Anesth. 2012;26(6):1083-93. [PubMed link]
  3. Larsen OH, Fenger-eriksen C, Christiansen K, Ingerslev J, Sørensen B. Diagnostic performance and therapeutic consequence of thromboelastometry activated by kaolin versus a panel of specific reagents. Anesthesiology. 2011;115(2):294-302. [PubMed link]

Leave a Comment

Scroll to Top
Verified by ExactMetrics